note MRI

Stimulation – control à 30 % differences

n  Spontaneous correlations = functional connectivity ?

ICA (independent component analysis)

Review : Calhoun NeuroImage 2008/ Cole Frontiers Sys Neur 2010

ICA : Comon Signal Processing 1994/ Bell Neural Computation 1995

ICA for fMRI: McKeown Human Brain Mapping 1998

ICA for resting fMRI: Kiviniemi NeuroImage 2003

ICA for FMRI software: MELODIC in FSL/ GIFT / Brain voyager

Pattern:

Beckmann phil trans toy soc b 2005 / Smith  PNAS 2009

Which area is activate with the task

Temporal characteristics:

n  Dynamic Causal Modelling friston Neuroimage 2003

1.     fit to FMRI data using Bayesian methods

2.     not yet proven for high-dimensional resting FMRI

n  Lag-based, e.g. Granger causality Gobel MRI 2003

1.     If timeseries B lags behind A then A causes B

2.     Haemodynamic variability a serious problem

Paper: Smith Neuroimage 2010 / rubinov neuroimage 2010 (graph theory)

Craddock MRM 2009 (applications of network matrix)

HCP – pushing spatial & temporal resolusion Feinberge PLoS 2010

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n  Functional Connectivity

Region 1 / seed à correlated ?

Region 2 / seed à correlated ?

n  Potential roles of resting-state FMRI in neuropsychiatric disorders

n   Disease mechanism

n   Diagnostics

n   Prognostics

n   Treatment efficacy ( seizure/ epilepsy)

è Paper : Soddu et al., Hum Brain Mapp 2011

n  Alzheimer biomarker

Greicius et al PNAS 2004

n  FTD pateint vs AD

Zhou et al brain. 2010